Endocrine Abstracts

Background: Insulin gene (INS) is known to be responsible for production of insulin by the pancreatic β-cells. It includes variable number of tandem repeats (VNTR) of oligonucleotide consequence (ACAGGGGT (G/C) (T/C) GGGG) in the promoter region (Bell et al, 1981,1982); being the gene involved in the susceptibility to various pathologies. The allele-specific PCR allows direct diagnosis of some genetically determined disorders is rather simple and precise. However, by toda...